Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effect of teriparatide combined with low-frequency pulsed electromagnetic field on hip fracture

Xiang Sun, Xuefeng Guo, Wen Cao, Qiang Dong

Department of Traumatology, Tianjin Hospital, Tianjin 300211, China;

For correspondence:- Qiang Dong Email: qiangdong452@yandex.com

Accepted: 26 September 2020 Published: 30 October 2020

Citation: Sun X, Guo X, Cao W, Dong Q. Therapeutic effect of teriparatide combined with low-frequency pulsed electromagnetic field on hip fracture. Trop J Pharm Res 2020; 19(10):2227-2233 doi: 10.4314/tjpr.v19i10.29

© 2020 The authors.
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Abstract

Purpose: To evaluate the therapeutic effect of teriparatide in combination with low-frequency pulsed electromagnetic field in the management of hip fracture.

Methods: Patients with hip fracture internal fixation and under conventional postoperative basic adjuvant therapy were compared with those patients who received teriparatide combined with low frequency pulsed electromagnetic field after operation. The content of Bone-Specific Alkaline Phosphatase (BALP), type I Procollagen Carboxy Terminal Propeptide (PICP), serum bone glaprotein (BGP), Ca²⁺, hip function and degree of bone scab formation were evaluated using Harris score and Fernadez-esteve scoring system. Kaplan-Meier survival curve was plotted to analyze differences in short-term prognosis of different postoperative adjuvant treatment measures.

Results: Harris score of the hip joint and the effect of bone formation in the experimental group were higher than that of the control group. The blood levels of BGP, BALP, PICP and serum Ca²⁺ in the experimental group were higher than that of the control group (p < 0.05). The plotted Kaplan-Meier survival curve indicates that the prognosis of the experimental group was better than that of control group (p < 0.05).

Conclusion: The adjuvant therapy of teriparatide combined with low-frequency pulsed electromagnetic field can improve the recovery function and enhance the prognosis of patients who underwent hip fracture surgery.

Keywords: Teriparatide; Low frequency pulsed electromagnetic field, hip fracture